Discovery of 1,5-Disubstituted Pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor

[Image: see text] A series of 1,5-disubstituted pyridones was identified as positive allosteric modulators (PAMs) of the metabotropic glutamate receptor 2 (mGluR2) via high throughput screening (HTS). Subsequent SAR exploration led to the identification of several compounds with improved in vitro ac...

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Main Authors: Cid, Jose María, Duvey, Guillaume, Cluzeau, Philippe, Nhem, Vanthea, Macary, Karim, Raux, Alexandre, Poirier, Nicolas, Muller, Jessica, Boléa, Christelle, Finn, Terry, Poli, Sonia, Epping-Jordan, Mark, Chamelot, Emilie, Derouet, Francis, Girard, Francoise, Macdonald, Gregor J., Vega, Juan Antonio, de Lucas, Ana Isabel, Matesanz, Encarnación, Lavreysen, Hilde, Linares, María Lourdes, Oehlrich, Daniel, Oyarzábal, Julen, Tresadern, Gary, Trabanco, Andrés A., Andrés, Jose Ignacio, Le Poul, Emmanuel, Imogai, Hassan, Lutjens, Robert, Rocher, Jean-Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2010
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368638/
https://ncbi.nlm.nih.gov/pubmed/22778815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn1000638
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