G-protein-coupled receptor structure: what can we learn?

Por Tobin, Andrew B
Publicado em 2009

The role of M(3)-muscarinic receptor signaling in insulin secretion

Por Kong, Kok Choi, Tobin, Andrew B
Publicado em 2011

G-protein-coupled receptor regulation of P2X(1) receptors does not involve direct channel phosphorylation

Por Vial, Catherine, Tobin, Andrew B., Evans, Richard J.
Publicado em 2004

Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling

Por Tobin, Andrew B., Butcher, Adrian J., Kong, Kok Choi
Publicado em 2008

An evolutionary perspective on the kinome of malaria parasites

Por Talevich, Eric, Tobin, Andrew B., Kannan, Natarajan, Doerig, Christian
Publicado em 2012

Employing novel animal models in the design of clinically efficacious GPCR ligands()

Por Bradley, Sophie J, Riaz, Sajjad A, Tobin, Andrew B
Publicado em 2014

British Pharmacological Society, 5th Focused Meeting on Cell Signalling: Matters arising …

Por Willars, Gary B, Tobin, Andrew B, Challiss, R A John
Publicado no Br J Pharmacol (2015)

Signalling of the M(3)-muscarinic receptor to the anti-apoptotic pathway

Por Budd, David C., Spragg, Elizabeth J., Ridd, Katie, Tobin, Andrew B.
Publicado em 2004

Regulation of p53 expression, phosphorylation and sub-cellular localisation by a G-protein coupled receptor

Por Solyakov, Lev, Sayan, Emre, Riley, Joan, Pointon, Amy, Tobin, Andrew B
Publicado em 2009

Stimulus Bias Provides Evidence for Conformational Constraints in the Structure of a G Protein-coupled Receptor

Por Gregory, Karen J., Sexton, Patrick M., Tobin, Andrew B., Christopoulos, Arthur
Publicado em 2012

The Proto-oncogene SET Interacts with Muscarinic Receptors and Attenuates Receptor Signaling

Por Simon, Violaine, Guidry, Jessie, Gettys, Thomas W., Tobin, Andrew B., Lanier, Stephen M.
Publicado em 2006

Influence of the Accessory Protein SET on M3 Muscarinic Receptor Phosphorylation and G Protein Coupling

Por Simon, Violaine, Oner, Sukru S., Cohen-Tannoudji, Joelle, Tobin, Andrew B., Lanier, Stephen M.
Publicado em 2012

FFA4/GPR120: Pharmacology and Therapeutic Opportunities

Por Milligan, Graeme, Alvarez-Curto, Elisa, Hudson, Brian D., Prihandoko, Rudi, Tobin, Andrew B.
Publicado no Trends Pharmacol Sci (2017)

Identification of Orthosteric and Allosteric Site Mutations in M(2) Muscarinic Acetylcholine Receptors That Contribute to Ligand-selective Signaling Bias

Por Gregory, Karen J., Hall, Nathan E., Tobin, Andrew B., Sexton, Patrick M., Christopoulos, Arthur
Publicado em 2010

Full and Partial Agonists of Muscarinic M(3) Receptors Reveal Single and Oscillatory Ca(2+) Responses by β(2)-Adrenoceptors

Por Kurian, Nisha, Hall, Caroline J., Wilkinson, Graeme F., Sullivan, Michael, Tobin, Andrew B., Willars, Gary B.
Publicado em 2009

ERK5 Activation by Gq-Coupled Muscarinic Receptors Is Independent of Receptor Internalization and β-Arrestin Recruitment

Por Sánchez-Fernández, Guzmán, Cabezudo, Sofía, García-Hoz, Carlota, Tobin, Andrew B., Mayor Jr, Federico, Ribas, Catalina
Publicado em 2013

Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling

Por Alvarez-Curto, Elisa, Inoue, Asuka, Jenkins, Laura, Raihan, Sheikh Zahir, Prihandoko, Rudi, Tobin, Andrew B., Milligan, Graeme
Publicado no J Biol Chem (2016)

β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle

Por Nuber, Susanne, Zabel, Ulrike, Lorenz, Kristina, Nuber, Andreas, Milligan, Graeme, Tobin, Andrew B., Lohse, Martin J., Hoffmann, Carsten
Publicado no Nature (2016)

Phosphorylation and regulation of a G protein–coupled receptor by protein kinase CK2

Por Torrecilla, Ignacio, Spragg, Elizabeth J., Poulin, Benoit, McWilliams, Phillip J., Mistry, Sharad C., Blaukat, Andree, Tobin, Andrew B.
Publicado em 2007

Engineered Hyperphosphorylation of the β(2)-Adrenoceptor Prolongs Arrestin-3 Binding and Induces Arrestin Internalization

Por Zindel, Diana, Butcher, Adrian J., Al-Sabah, Suleiman, Lanzerstorfer, Peter, Weghuber, Julian, Tobin, Andrew B., Bünemann, Moritz, Krasel, Cornelius
Publicado no Mol Pharmacol (2015)