β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle

(β-)Arrestins are important regulators of G-protein-coupled receptors (GPCRs)(1–3). They bind to active, phosphorylated GPCRs and thereby shut off ‘classical’ signalling to G proteins(3,4), trigger internalization of GPCRs via interaction with the clathrin machinery(5–7) and mediate signalling via ‘...

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Publicado en:Nature
Autores principales: Nuber, Susanne, Zabel, Ulrike, Lorenz, Kristina, Nuber, Andreas, Milligan, Graeme, Tobin, Andrew B., Lohse, Martin J., Hoffmann, Carsten
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5157050/
https://ncbi.nlm.nih.gov/pubmed/27007855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17198
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