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β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle
(β-)Arrestins are important regulators of G-protein-coupled receptors (GPCRs)(1–3). They bind to active, phosphorylated GPCRs and thereby shut off ‘classical’ signalling to G proteins(3,4), trigger internalization of GPCRs via interaction with the clathrin machinery(5–7) and mediate signalling via ‘...
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| Publicado en: | Nature |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5157050/ https://ncbi.nlm.nih.gov/pubmed/27007855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17198 |
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