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Conformational biosensors and domain-swapping reveal structural and functional differences between the β-arrestin isoforms
Desensitization, signaling and trafficking of G protein-coupled receptors (GPCRs) are critically regulated by multifunctional adaptor proteins, β-arrestins (βarrs). The two isoforms of βarrs (βarr1 and 2) share a high degree of sequence and structural similarity, still however, they often mediate di...
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| Udgivet i: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7099875/ https://ncbi.nlm.nih.gov/pubmed/31553900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.053 |
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