Conformational biosensors and domain-swapping reveal structural and functional differences between the β-arrestin isoforms

Desensitization, signaling and trafficking of G protein-coupled receptors (GPCRs) are critically regulated by multifunctional adaptor proteins, β-arrestins (βarrs). The two isoforms of βarrs (βarr1 and 2) share a high degree of sequence and structural similarity, still however, they often mediate di...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Ghosh, Eshan, Dwivedi, Hemlata, Baidya, Mithu, Srivastava, Ashish, Kumari, Punita, Stepniewski, Tomek, Kim, Hee Ryung, Lee, Mi-Hye, van Gastel, Jaana, Chaturvedi, Madhu, Roy, Debarati, Pandey, Shubhi, Maharana, Jagannath, Guixà‐Gonzàlez, Ramon, Luttrell, Louis M., Chung, Ka Young, Dutta, Somnath, Selent, Jana, Shukla, Arun K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7099875/
https://ncbi.nlm.nih.gov/pubmed/31553900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.053
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