Key phosphorylation sites in GPCRs orchestrate the contribution of β‐Arrestin 1 in ERK1/2 activation

β‐arrestins (βarrs) are key regulators of G protein‐coupled receptor (GPCR) signaling and trafficking, and their knockdown typically leads to a decrease in agonist‐induced ERK1/2 MAP kinase activation. Interestingly, for some GPCRs, knockdown of βarr1 augments agonist‐induced ERK1/2 phosphorylation...

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Publicado en:EMBO Rep
Main Authors: Baidya, Mithu, Kumari, Punita, Dwivedi‐Agnihotri, Hemlata, Pandey, Shubhi, Chaturvedi, Madhu, Stepniewski, Tomasz Maciej, Kawakami, Kouki, Cao, Yubo, Laporte, Stéphane A, Selent, Jana, Inoue, Asuka, Shukla, Arun K
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7507470/
https://ncbi.nlm.nih.gov/pubmed/32715625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949886
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