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Employing novel animal models in the design of clinically efficacious GPCR ligands()

The headline success of targeting GPCRs in human diseases has masked the fact that many GPCR drug discovery programmes fail. This is despite a substantial increase in our understanding of GPCR pharmacology that has provided an array of ligands that target both orthosteric and allosteric sites as wel...

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Detalhes bibliográficos
Main Authors: Bradley, Sophie J, Riaz, Sajjad A, Tobin, Andrew B
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989050/
https://ncbi.nlm.nih.gov/pubmed/24680437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceb.2013.12.002
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