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Employing novel animal models in the design of clinically efficacious GPCR ligands()
The headline success of targeting GPCRs in human diseases has masked the fact that many GPCR drug discovery programmes fail. This is despite a substantial increase in our understanding of GPCR pharmacology that has provided an array of ligands that target both orthosteric and allosteric sites as wel...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Elsevier
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989050/ https://ncbi.nlm.nih.gov/pubmed/24680437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceb.2013.12.002 |
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