Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling

G protein-coupled receptors (GPCRs) can initiate intracellular signaling cascades by coupling to an array of heterotrimeric G proteins and arrestin adaptor proteins. Understanding the contribution of each of these coupling options to GPCR signaling has been hampered by a paucity of tools to selectiv...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Alvarez-Curto, Elisa, Inoue, Asuka, Jenkins, Laura, Raihan, Sheikh Zahir, Prihandoko, Rudi, Tobin, Andrew B., Milligan, Graeme
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207144/
https://ncbi.nlm.nih.gov/pubmed/27852822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.754887
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