Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα(13) and β-arrestin-2

BACKGROUND AND PURPOSE: GPR35 is a poorly characterized G protein-coupled receptor at which kynurenic acid has been suggested to be the endogenous ligand. We wished to test this and develop assays appropriate for the study of this receptor. EXPERIMENTAL APPROACH: Human and rat orthologues of GPR35 w...

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Dettagli Bibliografici
Autori principali: Jenkins, Laura, Alvarez-Curto, Elisa, Campbell, Kate, de Munnik, Sabrina, Canals, Meritxell, Schlyer, Sabine, Milligan, Graeme
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2011
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041261/
https://ncbi.nlm.nih.gov/pubmed/20958291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01082.x
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