Differential manipulation of arrestin-3 binding to basal and agonist-activated G protein-coupled receptors

Non-visual arrestins interact with hundreds of different G protein-coupled receptors (GPCRs). Here we show that by introducing mutations into elements that directly bind receptors, the specificity of arrestin-3 can be altered. Several mutations in the two parts of the central “crest” of the arrestin...

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Publicado no:Cell Signal
Main Authors: Prokop, Susanne, Perry, Nicole A., Vishnivetskiy, Sergey A., Toth, Andras D., Inoue, Asuka, Milligan, Graeme, Iverson, Tina M., Hunyady, Laszlo, Gurevich, Vsevolod V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797668/
https://ncbi.nlm.nih.gov/pubmed/28461104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2017.04.021
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