Minireview: The Effects of Species Ortholog and SNP Variation on Receptors for Free Fatty Acids

Autor Hudson, Brian D., Murdoch, Hannah, Milligan, Graeme
Vydáno 2013

Physical and functional interaction between CB(1) cannabinoid receptors and β(2)-adrenoceptors

Autor Hudson, Brian D, Hébert, Terence E, Kelly, Melanie EM
Vydáno 2010

The Molecular Basis of Ligand Interaction at Free Fatty Acid Receptor 4 (FFA4/GPR120)

Autor Hudson, Brian D., Shimpukade, Bharat, Milligan, Graeme, Ulven, Trond
Vydáno 2014

Treatment of Type 2 Diabetes by Free Fatty Acid Receptor Agonists

Autor Watterson, Kenneth R., Hudson, Brian D., Ulven, Trond, Milligan, Graeme
Vydáno 2014

Extracellular Ionic Locks Determine Variation in Constitutive Activity and Ligand Potency between Species Orthologs of the Free Fatty Acid Receptors FFA2 and FFA3

Autor Hudson, Brian D., Tikhonova, Irina G., Pandey, Sunil K., Ulven, Trond, Milligan, Graeme
Vydáno 2012

FFA4/GPR120: Pharmacology and Therapeutic Opportunities

Autor Milligan, Graeme, Alvarez-Curto, Elisa, Hudson, Brian D., Prihandoko, Rudi, Tobin, Andrew B.
Vydáno v Trends Pharmacol Sci (2017)

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

Autor Hudson, Brian D., Christiansen, Elisabeth, Tikhonova, Irina G., Grundmann, Manuel, Kostenis, Evi, Adams, David R., Ulven, Trond, Milligan, Graeme
Vydáno 2012

Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands

Autor Sergeev, Eugenia, Hansen, Anders Højgaard, Pandey, Sunil K., MacKenzie, Amanda E., Hudson, Brian D., Ulven, Trond, Milligan, Graeme
Vydáno v J Biol Chem (2016)

Concomitant Action of Structural Elements and Receptor Phosphorylation Determines Arrestin-3 Interaction with the Free Fatty Acid Receptor FFA4

Autor Butcher, Adrian J., Hudson, Brian D., Shimpukade, Bharat, Alvarez-Curto, Elisa, Prihandoko, Rudi, Ulven, Trond, Milligan, Graeme, Tobin, Andrew B.
Vydáno 2014

Mechanism and Function of Drosophila capa GPCR: A Desiccation Stress-Responsive Receptor with Functional Homology to Human NeuromedinU Receptor

Autor Terhzaz, Selim, Cabrero, Pablo, Robben, Joris H., Radford, Jonathan C., Hudson, Brian D., Milligan, Graeme, Dow, Julian A. T., Davies, Shireen-A.
Vydáno 2012

A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias

Autor Sergeev, Eugenia, Hansen, Anders Højgaard, Bolognini, Daniele, Kawakami, Kouki, Kishi, Takayuki, Aoki, Junken, Ulven, Trond, Inoue, Asuka, Hudson, Brian D., Milligan, Graeme
Vydáno v Sci Rep (2017)

Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84

Autor Mahmud, Zobaer Al, Jenkins, Laura, Ulven, Trond, Labéguère, Frédéric, Gosmini, Romain, De Vos, Steve, Hudson, Brian D., Tikhonova, Irina G., Milligan, Graeme
Vydáno v Sci Rep (2017)

The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Ther...

Autor Hudson, Brian D., Shimpukade, Bharat, Mackenzie, Amanda E., Butcher, Adrian J., Pediani, John D., Christiansen, Elisabeth, Heathcote, Helen, Tobin, Andrew B., Ulven, Trond, Milligan, Graeme
Vydáno 2013

Receptor selectivity between the G proteins Gα(12) and Gα(13) is defined by a single leucine-to-isoleucine variation

Autor Mackenzie, Amanda E., Quon, Tezz, Lin, Li-Chiung, Hauser, Alexander S., Jenkins, Laura, Inoue, Asuka, Tobin, Andrew B., Gloriam, David E., Hudson, Brian D., Milligan, Graeme
Vydáno v FASEB J (2019)

Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists: IDENTIFICATION OF THE STRUCTURAL AND CHEMICAL REQUIREMENTS FOR SELECTIVE ACTIVATION OF FFA2 VERSUS FFA3

Autor Schmidt, Johannes, Smith, Nicola J., Christiansen, Elisabeth, Tikhonova, Irina G., Grundmann, Manuel, Hudson, Brian D., Ward, Richard J., Drewke, Christel, Milligan, Graeme, Kostenis, Evi, Ulven, Trond
Vydáno 2011

Extracellular Loop 2 of the Free Fatty Acid Receptor 2 Mediates Allosterism of a Phenylacetamide Ago-Allosteric Modulator

Autor Smith, Nicola J., Ward, Richard J., Stoddart, Leigh A., Hudson, Brian D., Kostenis, Evi, Ulven, Trond, Morris, Joanne C., Tränkle, Christian, Tikhonova, Irina G., Adams, David R., Milligan, Graeme
Vydáno 2011

The Antiallergic Mast Cell Stabilizers Lodoxamide and Bufrolin as the First High and Equipotent Agonists of Human and Rat GPR35

Autor MacKenzie, Amanda E., Caltabiano, Gianluigi, Kent, Toby C., Jenkins, Laura, McCallum, Jennifer E., Hudson, Brian D., Nicklin, Stuart A., Fawcett, Lindsay, Markwick, Rachel, Charlton, Steven J., Milligan, Graeme
Vydáno 2014

Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4

Autor Watterson, Kenneth R., Hansen, Steffen V. F., Hudson, Brian D., Alvarez-Curto, Elisa, Raihan, Sheikh Zahir, Azevedo, Carlos M. G., Martin, Gabriel, Dunlop, Julia, Yarwood, Stephen J., Ulven, Trond, Milligan, Graeme
Vydáno v Mol Pharmacol (2017)

Defining the Molecular Basis for the First Potent and Selective Orthosteric Agonists of the FFA2 Free Fatty Acid Receptor

Autor Hudson, Brian D., Due-Hansen, Maria E., Christiansen, Elisabeth, Hansen, Anna Mette, Mackenzie, Amanda E., Murdoch, Hannah, Pandey, Sunil K., Ward, Richard J., Marquez, Rudi, Tikhonova, Irina G., Ulven, Trond, Milligan, Graeme
Vydáno 2013

Structure–Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators

Autor Ulven, Elisabeth Rexen, Quon, Tezz, Sergeev, Eugenia, Barki, Natasja, Brvar, Matjaz, Hudson, Brian D., Dutta, Palash, Hansen, Anders Højgaard, Bielefeldt, Line Ø., Tobin, Andrew B., McKenzie, Christine J., Milligan, Graeme, Ulven, Trond
Vydáno v J Med Chem (2020)