Extracellular Loop 2 of the Free Fatty Acid Receptor 2 Mediates Allosterism of a Phenylacetamide Ago-Allosteric Modulator

Allosteric agonists are powerful tools for exploring the pharmacology of closely related G protein-coupled receptors that have nonselective endogenous ligands, such as the short chain fatty acids at free fatty acid receptors 2 and 3 (FFA2/GPR43 and FFA3/GPR41, respectively). We explored the molecula...

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Bibliografiset tiedot
Päätekijät: Smith, Nicola J., Ward, Richard J., Stoddart, Leigh A., Hudson, Brian D., Kostenis, Evi, Ulven, Trond, Morris, Joanne C., Tränkle, Christian, Tikhonova, Irina G., Adams, David R., Milligan, Graeme
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127537/
https://ncbi.nlm.nih.gov/pubmed/21498659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.070789
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