The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Therapeutic Agonism

TUG-891 [3-(4-((4-fluoro-4′-methyl-[1,1′-biphenyl]-2-yl)methoxy)phenyl)propanoic acid] was recently described as a potent and selective agonist for the long chain free fatty acid (LCFA) receptor 4 (FFA4; previously G protein–coupled receptor 120, or GPR120). Herein, we have used TUG-891 to further d...

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Main Authors: Hudson, Brian D., Shimpukade, Bharat, Mackenzie, Amanda E., Butcher, Adrian J., Pediani, John D., Christiansen, Elisabeth, Heathcote, Helen, Tobin, Andrew B., Ulven, Trond, Milligan, Graeme
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807074/
https://ncbi.nlm.nih.gov/pubmed/23979972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.087783
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