Minireview: The Effects of Species Ortholog and SNP Variation on Receptors for Free Fatty Acids

Por Hudson, Brian D., Murdoch, Hannah, Milligan, Graeme
Publicado em 2013

Physical and functional interaction between CB(1) cannabinoid receptors and β(2)-adrenoceptors

Por Hudson, Brian D, Hébert, Terence E, Kelly, Melanie EM
Publicado em 2010

The Molecular Basis of Ligand Interaction at Free Fatty Acid Receptor 4 (FFA4/GPR120)

Por Hudson, Brian D., Shimpukade, Bharat, Milligan, Graeme, Ulven, Trond
Publicado em 2014

Treatment of Type 2 Diabetes by Free Fatty Acid Receptor Agonists

Por Watterson, Kenneth R., Hudson, Brian D., Ulven, Trond, Milligan, Graeme
Publicado em 2014

Extracellular Ionic Locks Determine Variation in Constitutive Activity and Ligand Potency between Species Orthologs of the Free Fatty Acid Receptors FFA2 and FFA3

Por Hudson, Brian D., Tikhonova, Irina G., Pandey, Sunil K., Ulven, Trond, Milligan, Graeme
Publicado em 2012

FFA4/GPR120: Pharmacology and Therapeutic Opportunities

Por Milligan, Graeme, Alvarez-Curto, Elisa, Hudson, Brian D., Prihandoko, Rudi, Tobin, Andrew B.
Publicado no Trends Pharmacol Sci (2017)

Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

Por Hudson, Brian D., Christiansen, Elisabeth, Tikhonova, Irina G., Grundmann, Manuel, Kostenis, Evi, Adams, David R., Ulven, Trond, Milligan, Graeme
Publicado em 2012

Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands

Por Sergeev, Eugenia, Hansen, Anders Højgaard, Pandey, Sunil K., MacKenzie, Amanda E., Hudson, Brian D., Ulven, Trond, Milligan, Graeme
Publicado no J Biol Chem (2016)

Concomitant Action of Structural Elements and Receptor Phosphorylation Determines Arrestin-3 Interaction with the Free Fatty Acid Receptor FFA4

Por Butcher, Adrian J., Hudson, Brian D., Shimpukade, Bharat, Alvarez-Curto, Elisa, Prihandoko, Rudi, Ulven, Trond, Milligan, Graeme, Tobin, Andrew B.
Publicado em 2014

Mechanism and Function of Drosophila capa GPCR: A Desiccation Stress-Responsive Receptor with Functional Homology to Human NeuromedinU Receptor

Por Terhzaz, Selim, Cabrero, Pablo, Robben, Joris H., Radford, Jonathan C., Hudson, Brian D., Milligan, Graeme, Dow, Julian A. T., Davies, Shireen-A.
Publicado em 2012

A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias

Por Sergeev, Eugenia, Hansen, Anders Højgaard, Bolognini, Daniele, Kawakami, Kouki, Kishi, Takayuki, Aoki, Junken, Ulven, Trond, Inoue, Asuka, Hudson, Brian D., Milligan, Graeme
Publicado no Sci Rep (2017)

Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84

Por Mahmud, Zobaer Al, Jenkins, Laura, Ulven, Trond, Labéguère, Frédéric, Gosmini, Romain, De Vos, Steve, Hudson, Brian D., Tikhonova, Irina G., Milligan, Graeme
Publicado no Sci Rep (2017)

The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Ther...

Por Hudson, Brian D., Shimpukade, Bharat, Mackenzie, Amanda E., Butcher, Adrian J., Pediani, John D., Christiansen, Elisabeth, Heathcote, Helen, Tobin, Andrew B., Ulven, Trond, Milligan, Graeme
Publicado em 2013

Receptor selectivity between the G proteins Gα(12) and Gα(13) is defined by a single leucine-to-isoleucine variation

Por Mackenzie, Amanda E., Quon, Tezz, Lin, Li-Chiung, Hauser, Alexander S., Jenkins, Laura, Inoue, Asuka, Tobin, Andrew B., Gloriam, David E., Hudson, Brian D., Milligan, Graeme
Publicado no FASEB J (2019)

Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists: IDENTIFICATION OF THE STRUCTURAL AND CHEMICAL REQUIREMENTS FOR SELECTIVE ACTIVATION OF FFA2 VERSUS FFA3

Por Schmidt, Johannes, Smith, Nicola J., Christiansen, Elisabeth, Tikhonova, Irina G., Grundmann, Manuel, Hudson, Brian D., Ward, Richard J., Drewke, Christel, Milligan, Graeme, Kostenis, Evi, Ulven, Trond
Publicado em 2011

Extracellular Loop 2 of the Free Fatty Acid Receptor 2 Mediates Allosterism of a Phenylacetamide Ago-Allosteric Modulator

Por Smith, Nicola J., Ward, Richard J., Stoddart, Leigh A., Hudson, Brian D., Kostenis, Evi, Ulven, Trond, Morris, Joanne C., Tränkle, Christian, Tikhonova, Irina G., Adams, David R., Milligan, Graeme
Publicado em 2011

The Antiallergic Mast Cell Stabilizers Lodoxamide and Bufrolin as the First High and Equipotent Agonists of Human and Rat GPR35

Por MacKenzie, Amanda E., Caltabiano, Gianluigi, Kent, Toby C., Jenkins, Laura, McCallum, Jennifer E., Hudson, Brian D., Nicklin, Stuart A., Fawcett, Lindsay, Markwick, Rachel, Charlton, Steven J., Milligan, Graeme
Publicado em 2014

Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4

Por Watterson, Kenneth R., Hansen, Steffen V. F., Hudson, Brian D., Alvarez-Curto, Elisa, Raihan, Sheikh Zahir, Azevedo, Carlos M. G., Martin, Gabriel, Dunlop, Julia, Yarwood, Stephen J., Ulven, Trond, Milligan, Graeme
Publicado no Mol Pharmacol (2017)

Defining the Molecular Basis for the First Potent and Selective Orthosteric Agonists of the FFA2 Free Fatty Acid Receptor

Por Hudson, Brian D., Due-Hansen, Maria E., Christiansen, Elisabeth, Hansen, Anna Mette, Mackenzie, Amanda E., Murdoch, Hannah, Pandey, Sunil K., Ward, Richard J., Marquez, Rudi, Tikhonova, Irina G., Ulven, Trond, Milligan, Graeme
Publicado em 2013

Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes

Por Christiansen, Elisabeth, Hansen, Steffen V. F., Urban, Christian, Hudson, Brian D., Wargent, Edward T., Grundmann, Manuel, Jenkins, Laura, Zaibi, Mohamed, Stocker, Claire J., Ullrich, Susanne, Kostenis, Evi, Kassack, Matthias U., Milligan, Graeme, Cawthorne, Michael A., Ulven, Trond
Publicado em 2013