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Engineered Hyperphosphorylation of the β(2)-Adrenoceptor Prolongs Arrestin-3 Binding and Induces Arrestin Internalization
G protein–coupled receptor phosphorylation plays a major role in receptor desensitization and arrestin binding. It is, however, unclear how distinct receptor phosphorylation patterns may influence arrestin binding and subsequent trafficking. Here we engineer phosphorylation sites into the C-terminal...
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| Publicado no: | Mol Pharmacol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4293452/ https://ncbi.nlm.nih.gov/pubmed/25425623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.095422 |
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