The GIP Receptor Displays Higher Basal Activity than the GLP-1 Receptor but Does Not Recruit GRK2 or Arrestin3 Effectively

BACKGROUND AND OBJECTIVES: Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are important regulators of insulin secretion, and their functional loss is an early characteristic of type 2 diabetes mellitus (T2DM). Pharmacological levels of GLP-1, but not GIP, can...

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Main Authors: Al-Sabah, Suleiman, Al-Fulaij, Munya, Shaaban, Ghina, Ahmed, Hanadi A., Mann, Rosalind J., Donnelly, Dan, Bünemann, Moritz, Krasel, Cornelius
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156404/
https://ncbi.nlm.nih.gov/pubmed/25191754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106890
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