Integrating platelet and coagulation activation in fibrin clot formation

von Swieringa, Frauke, Spronk, Henri M.H., Heemskerk, Johan W.M., van der Meijden, Paola E.J.
Veröffentlicht in Res Pract Thromb Haemost (2018)

Whole Blood Based Multiparameter Assessment of Thrombus Formation in Standard Microfluidic Devices to Proxy In Vivo Haemostasis and Thrombosis

von Provenzale, Isabella, Brouns, Sanne L. N., van der Meijden, Paola E. J., Swieringa, Frauke, Heemskerk, Johan W. M.
Veröffentlicht in Micromachines (Basel) (2019)

Rate-limiting roles of the tenase complex of factors VIII and IX in platelet procoagulant activity and formation of platelet-fibrin thrombi under flow

von Swieringa, Frauke, Kuijpers, Marijke J. E., Lamers, Moniek M. E., van der Meijden, Paola E. J., Heemskerk, Johan W. M.
Veröffentlicht in Haematologica (2015)

Key role of integrin α(IIb)β(3) signaling to Syk kinase in tissue factor-induced thrombin generation

von van der Meijden, Paola E. J., Feijge, Marion A. H., Swieringa, Frauke, Gilio, Karen, Nergiz-Unal, Reyhan, Hamulyák, Karly, Heemskerk, Johan W. M.
Veröffentlicht 2012

Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow

von Whyte, Claire S., Swieringa, Frauke, Mastenbroek, Tom G., Lionikiene, Ausra S., Lancé, Marcus D., van der Meijden, Paola E. J., Heemskerk, Johan W. M., Mutch, Nicola J.
Veröffentlicht in Blood (2015)

Combined Quantification of the Global Proteome, Phosphoproteome, and Proteolytic Cleavage to Characterize Altered Platelet Functions in the Human Scott Syndrome

von Solari, Fiorella A., Mattheij, Nadine J.A., Burkhart, Julia M., Swieringa, Frauke, Collins, Peter W., Cosemans, Judith M.E.M., Sickmann, Albert, Heemskerk, Johan W.M., Zahedi, René P.
Veröffentlicht in Mol Cell Proteomics (2016)

Assessment of a complete and classified platelet proteome from genome-wide transcripts of human platelets and megakaryocytes covering platelet functions

von Huang, Jingnan, Swieringa, Frauke, Solari, Fiorella A., Provenzale, Isabella, Grassi, Luigi, De Simone, Ilaria, Baaten, Constance C. F. M. J., Cavill, Rachel, Sickmann, Albert, Frontini, Mattia, Heemskerk, Johan W. M.
Veröffentlicht in Sci Rep (2021)

Suppressive Role of Tissue Factor Pathway Inhibitor-α in Platelet-Dependent Fibrin Formation under Flow Is Restricted to Low Procoagulant Strength

von Thomassen, Stella, Mastenbroek, Tom G., Swieringa, Frauke, Winckers, Kristien, Feijge, Marion A.H., Schrijver, Roy, Cosemans, Judith M.E.M., Maroney, Susan A., Mast, Alan E., Hackeng, Tilman M., Heemskerk, Johan W.M.
Veröffentlicht in Thromb Haemost (2018)

Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects

von Baaten, Constance C. F. M. J., Swieringa, Frauke, Misztal, Tomasz, Mastenbroek, Tom G., Feijge, Marion A. H., Bock, Paul E., Donners, Marjo M. P. C., Collins, Peter W., Li, Renhao, van der Meijden, Paola E. J., Heemskerk, Johan W. M.
Veröffentlicht in Blood Adv (2018)

Gradual increase in thrombogenicity of juvenile platelets formed upon offset of prasugrel medication

von Baaten, Constance C. F. M. J., Veenstra, Leo F., Wetzels, Rick, van Geffen, Johanna P., Swieringa, Frauke, de Witt, Susanne M., Henskens, Yvonne M. C., Crijns, Harry, Nylander, Sven, van Giezen, J. J. J., Heemskerk, Johan W. M., van der Meijden, Paola E. J.
Veröffentlicht in Haematologica (2015)

AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation

von Lepropre, Sophie, Kautbally, Shakeel, Octave, Marie, Ginion, Audrey, Onselaer, Marie-Blanche, Steinberg, Gregory R., Kemp, Bruce E., Hego, Alexandre, Wéra, Odile, Brouns, Sanne, Swieringa, Frauke, Giera, Martin, Darley-Usmar, Victor M., Ambroise, Jérôme, Guigas, Bruno, Heemskerk, Johan, Bertrand, Luc, Oury, Cécile, Beauloye, Christophe, Horman, Sandrine
Veröffentlicht in Blood (2018)

Identification of platelet function defects by multi-parameter assessment of thrombus formation

von de Witt, Susanne M., Swieringa, Frauke, Cavill, Rachel, Lamers, Moniek M. E., van Kruchten, Roger, Mastenbroek, Tom, Baaten, Constance, Coort, Susan, Pugh, Nicholas, Schulz, Ansgar, Scharrer, Inge, Jurk, Kerstin, Zieger, Barbara, Clemetson, Kenneth J., Farndale, Richard W., Heemskerk, Johan W. M., Cosemans, Judith M.E.M.
Veröffentlicht 2014

Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy

von Baaten, Constance C. F. M. J., Moenen, Floor C. J. I., Henskens, Yvonne M. C., Swieringa, Frauke, Wetzels, Rick J. H., van Oerle, René, Heijnen, Harry F. G., ten Cate, Hugo, Holloway, Graham P., Beckers, Erik A. M., Heemskerk, Johan W. M., van der Meijden, Paola E. J.
Veröffentlicht in Haematologica (2018)

Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome

von van Geffen, Johanna P., Swieringa, Frauke, van Kuijk, Kim, Tullemans, Bibian M. E., Solari, Fiorella A., Peng, Bing, Clemetson, Kenneth J., Farndale, Richard W., Dubois, Ludwig J., Sickmann, Albert, Zahedi, René P., Ahrends, Robert, Biessen, Erik A. L., Sluimer, Judith C., Heemskerk, Johan W. M., Kuijpers, Marijke J. E.
Veröffentlicht in Sci Rep (2020)

Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation

von Brouns, Sanne L. N., van Geffen, Johanna P., Campello, Elena, Swieringa, Frauke, Spiezia, Luca, van Oerle, René, Provenzale, Isabella, Verdoold, Remco, Farndale, Richard W., Clemetson, Kenneth J., Spronk, Henri M. H., van der Meijden, Paola E. J., Cavill, Rachel, Kuijpers, Marijke J. E., Castoldi, Elisabetta, Simioni, Paolo, Heemskerk, Johan W. M.
Veröffentlicht in Sci Rep (2020)

High-throughput elucidation of thrombus formation reveals sources of platelet function variability

von van Geffen, Johanna P., Brouns, Sanne L.N., Batista, Joana, McKinney, Harriet, Kempster, Carly, Nagy, Magdolna, Sivapalaratnam, Suthesh, Baaten, Constance C.F.M.J., Bourry, Nikki, Frontini, Mattia, Jurk, Kerstin, Krause, Manuela, Pillitteri, Daniele, Swieringa, Frauke, Verdoold, Remco, Cavill, Rachel, Kuijpers, Marijke J. E., Ouwehand, Willem H., Downes, Kate, Heemskerk, Johan W.M.
Veröffentlicht in Haematologica (2019)

Coated platelets function in platelet-dependent fibrin formation via integrin α(IIb)β(3) and transglutaminase factor XIII

von Mattheij, Nadine J.A., Swieringa, Frauke, Mastenbroek, Tom G., Berny-Lang, Michelle A., May, Frauke, Baaten, Constance C.F.M.J., van der Meijden, Paola E.J., Henskens, Yvonne M.C., Beckers, Erik A.M., Suylen, Dennis P.L., Nolte, Marc W., Hackeng, Tilman M., McCarty, Owen J.T., Heemskerk, Johan W.M., Cosemans, Judith M.E.M.
Veröffentlicht in Haematologica (2016)

Impaired iloprost-induced platelet inhibition and phosphoproteome changes in patients with confirmed pseudohypoparathyroidism type Ia, linked to genetic mutations in GNAS

von Swieringa, Frauke, Solari, Fiorella A., Pagel, Oliver, Beck, Florian, Huang, Jingnan, Feijge, Marion A. H., Jurk, Kerstin, Körver-Keularts, Irene M. L. W., Mattheij, Nadine J. A., Faber, Jörg, Pohlenz, Joachim, Russo, Alexandra, Stumpel, Connie T. R. M., Schrander, Dirk E., Zieger, Barbara, van der Meijden, Paola E. J., Zahedi, René P., Sickmann, Albert, Heemskerk, Johan W. M.
Veröffentlicht in Sci Rep (2020)

A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding

von Baaten, Constance C. F. M. J., Meacham, Stuart, de Witt, Susanne M., Feijge, Marion A. H., Adams, David J., Akkerman, Jan-Willem N., Cosemans, Judith M. E. M., Grassi, Luigi, Jupe, Steve, Kostadima, Myrto, Mattheij, Nadine J. A., Prins, Martin H., Ramirez-Solis, Ramiro, Soehnlein, Oliver, Swieringa, Frauke, Weber, Christian, White, Jacqueline K., Ouwehand, Willem H., Heemskerk, Johan W. M.
Veröffentlicht in Blood (2018)