Key role of integrin α(IIb)β(3) signaling to Syk kinase in tissue factor-induced thrombin generation

The fibrin(ogen) receptor, integrin α(IIb)β(3), has a well-established role in platelet spreading, aggregation and clot retraction. How α(IIb)β(3) contributes to platelet-dependent coagulation is less well resolved. Here, we demonstrate that the potent suppressing effect of clinically used α(IIb)β(3...

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Detalhes bibliográficos
Main Authors: van der Meijden, Paola E. J., Feijge, Marion A. H., Swieringa, Frauke, Gilio, Karen, Nergiz-Unal, Reyhan, Hamulyák, Karly, Heemskerk, Johan W. M.
Formato: Artigo
Idioma:Inglês
Publicado em: SP Birkhäuser Verlag Basel 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3445795/
https://ncbi.nlm.nih.gov/pubmed/22669259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-012-1033-2
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