Dual Mechanism of Integrin α(IIb)β(3) Closure in Procoagulant Platelets

Aggregation of platelets via activated integrin α(IIb)β(3) is a prerequisite for thrombus formation. Phosphatidylserine-exposing platelets with a key role in the coagulation process disconnect from a thrombus by integrin inactivation via an unknown mechanism. Here we show that α(IIb)β(3) inactivatio...

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Main Authors: Mattheij, Nadine J. A., Gilio, Karen, van Kruchten, Roger, Jobe, Shawn M., Wieschhaus, Adam J., Chishti, Athar H., Collins, Peter, Heemskerk, Johan W. M., Cosemans, Judith M. E. M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650371/
https://ncbi.nlm.nih.gov/pubmed/23519467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.428359
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