Platelet Isolation and Activation Assays

Por Burzynski, Laura C., Pugh, Nicholas, Clarke, Murray C.H.
Publicado no Bio Protoc (2019)

Dynamic analysis of platelet deposition to resolve platelet adhesion receptor activity in whole blood at arterial shear rate

Por Pugh, Nicholas, Bihan, Dominique, Perry, David J., Farndale, Richard W.
Publicado no Platelets (2015)

Extracellular chloride is required for efficient platelet aggregation

Por Taylor, Kirk A., Wilson, Darren G. S., Harper, Matthew T., Pugh, Nicholas
Publicado no Platelets (2017)

Pericellular Ca(2+) recycling potentiates thrombin-evoked Ca(2+) signals in human platelets

Por Sage, Stewart O, Pugh, Nicholas, Farndale, Richard W, Harper, Alan G S
Publicado em 2013

Agonist-Evoked Increases in Intra-Platelet Zinc Couple to Functional Responses

Por Ahmed, Niaz S., Lopes Pires, Maria E., Taylor, Kirk A., Pugh, Nicholas
Publicado no Thromb Haemost (2019)

Differential integrin activity mediated by platelet collagen receptor engagement under flow conditions

Por Pugh, Nicholas, Maddox, Ben D., Bihan, Dominique, Taylor, Kirk A., Mahaut-Smith, Martyn P., Farndale, Richard W.
Publicado no Thromb Haemost (2017)

Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood

Por Pugh, Nicholas, Simpson, Anna M. C., Smethurst, Peter A., de Groot, Philip G., Raynal, Nicolas, Farndale, Richard W.
Publicado em 2010

Mapping of Potent and Specific Binding Motifs, GLOGEN and GVOGEA, for Integrin α1β1 Using Collagen Toolkits II and III

Por Hamaia, Samir W., Pugh, Nicholas, Raynal, Nicolas, Némoz, Benjamin, Stone, Rachael, Gullberg, Donald, Bihan, Dominique, Farndale, Richard W.
Publicado em 2012

The properties conferred upon triple-helical collagen-mimetic peptides by the presence of cysteine residues

Por Slatter, David A., Bihan, Dominique G., Jarvis, Gavin E., Stone, Rachael, Pugh, Nicholas, Giddu, Sumana, Farndale, Richard W.
Publicado em 2012

Crosslinking and composition influence the surface properties, mechanical stiffness and cell reactivity of collagen-based films

Por Grover, Chloe N., Gwynne, Jessica H., Pugh, Nicholas, Hamaia, Samir, Farndale, Richard W., Best, Serena M., Cameron, Ruth E.
Publicado em 2012

MMP‐13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation

Por Howes, Joanna‐Marie, Pugh, Nicholas, Hamaia, Samir W., Jung, Stephanie M., Knäuper, Vera, Malcor, Jean‐Daniel, Farndale, Richard W.
Publicado no Res Pract Thromb Haemost (2018)

First Analysis of a Bacterial Collagen-Binding Protein with Collagen Toolkits: Promiscuous Binding of YadA to Collagens May Explain How YadA Interferes with Host Processes

Por Leo, Jack C., Elovaara, Heli, Bihan, Dominique, Pugh, Nicholas, Kilpinen, Sami K., Raynal, Nicolas, Skurnik, Mikael, Farndale, Richard W., Goldman, Adrian
Publicado em 2010

Constitutive Dimerization of Glycoprotein VI (GPVI) in Resting Platelets Is Essential for Binding to Collagen and Activation in Flowing Blood

Por Jung, Stephanie M., Moroi, Masaaki, Soejima, Kenji, Nakagaki, Tomohiro, Miura, Yoshiki, Berndt, Michael C., Gardiner, Elizabeth E., Howes, Joanna-Marie, Pugh, Nicholas, Bihan, Dominique, Watson, Steve P., Farndale, Richard W.
Publicado em 2012

Stapled peptides as a new technology to investigate protein–protein interactions in human platelets

Por Iegre, Jessica, Ahmed, Niaz S., Gaynord, Josephine S., Wu, Yuteng, Herlihy, Kara M., Tan, Yaw Sing, Lopes-Pires, Maria E., Jha, Rupam, Lau, Yu Heng, Sore, Hannah F., Verma, Chandra, O' Donovan, Daniel H., Pugh, Nicholas, Spring, David R.
Publicado no Chem Sci (2018)

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

Por Barrow, Alexander David, Raynal, Nicolas, Andersen, Thomas Levin, Slatter, David A., Bihan, Dominique, Pugh, Nicholas, Cella, Marina, Kim, Taesoo, Rho, Jaerang, Negishi-Koga, Takako, Delaisse, Jean-Marie, Takayanagi, Hiroshi, Lorenzo, Joseph, Colonna, Marco, Farndale, Richard W., Choi, Yongwon, Trowsdale, John
Publicado em 2011

Identification of platelet function defects by multi-parameter assessment of thrombus formation

Por de Witt, Susanne M., Swieringa, Frauke, Cavill, Rachel, Lamers, Moniek M. E., van Kruchten, Roger, Mastenbroek, Tom, Baaten, Constance, Coort, Susan, Pugh, Nicholas, Schulz, Ansgar, Scharrer, Inge, Jurk, Kerstin, Zieger, Barbara, Clemetson, Kenneth J., Farndale, Richard W., Heemskerk, Johan W. M., Cosemans, Judith M.E.M.
Publicado em 2014