Constitutive Dimerization of Glycoprotein VI (GPVI) in Resting Platelets Is Essential for Binding to Collagen and Activation in Flowing Blood

The platelet collagen receptor glycoprotein VI (GPVI) has been suggested to function as a dimer, with increased affinity for collagen. Dissociation constants (K(d)) obtained by measuring recombinant GPVI binding to collagenous substrates showed that GPVI dimers bind with high affinity to tandem GPO...

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Библиографические подробности
Главные авторы: Jung, Stephanie M., Moroi, Masaaki, Soejima, Kenji, Nakagaki, Tomohiro, Miura, Yoshiki, Berndt, Michael C., Gardiner, Elizabeth E., Howes, Joanna-Marie, Pugh, Nicholas, Bihan, Dominique, Watson, Steve P., Farndale, Richard W.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
Предметы:
Glycobiology and Extracellular Matrices
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436176/
https://ncbi.nlm.nih.gov/pubmed/22773837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.359125
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