Constitutive Dimerization of Glycoprotein VI (GPVI) in Resting Platelets Is Essential for Binding to Collagen and Activation in Flowing Blood

The platelet collagen receptor glycoprotein VI (GPVI) has been suggested to function as a dimer, with increased affinity for collagen. Dissociation constants (K(d)) obtained by measuring recombinant GPVI binding to collagenous substrates showed that GPVI dimers bind with high affinity to tandem GPO...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jung, Stephanie M., Moroi, Masaaki, Soejima, Kenji, Nakagaki, Tomohiro, Miura, Yoshiki, Berndt, Michael C., Gardiner, Elizabeth E., Howes, Joanna-Marie, Pugh, Nicholas, Bihan, Dominique, Watson, Steve P., Farndale, Richard W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2012
Pynciau:
Glycobiology and Extracellular Matrices
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436176/
https://ncbi.nlm.nih.gov/pubmed/22773837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.359125
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