Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets

ESSENTIALS: Dimeric high‐affinity collagen receptor glycoprotein VI (GPVI) is present on resting platelets. Spatio‐temporal organization of platelet GPVI‐dimers was evaluated using advanced microscopy. Upon platelet adhesion to collagenous substrates, GPVI‐dimers coalesce to form clusters. Clusterin...

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Udgivet i:J Thromb Haemost
Main Authors: Poulter, N. S., Pollitt, A. Y., Owen, D. M., Gardiner, E. E., Andrews, R. K., Shimizu, H., Ishikawa, D., Bihan, D., Farndale, R. W., Moroi, M., Watson, S. P., Jung, S. M.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347898/
https://ncbi.nlm.nih.gov/pubmed/28058806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13613
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