Platelet collagen receptor Glycoprotein VI‐dimer recognizes fibrinogen and fibrin through their D‐domains, contributing to platelet adhesion and activation during thrombus formation

ESSENTIALS: Glycoprotein VI (GPVI) binds collagen, starting thrombogenesis, and fibrin, stabilizing thrombi. GPVI‐dimers, not monomers, recognize immobilized fibrinogen and fibrin through their D‐domains. Collagen, D‐fragment and D‐dimer may share a common or proximate binding site(s) on GPVI‐dimer....

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Publié dans:J Thromb Haemost
Auteurs principaux: Induruwa, I., Moroi, M., Bonna, A., Malcor, J.‐D., Howes, J.‐M., Warburton, E. A., Farndale, R. W., Jung, S. M.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2018
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PLATELETS
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5838801/
https://ncbi.nlm.nih.gov/pubmed/29210180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13919
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