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Platelet collagen receptor Glycoprotein VI‐dimer recognizes fibrinogen and fibrin through their D‐domains, contributing to platelet adhesion and activation during thrombus formation
ESSENTIALS: Glycoprotein VI (GPVI) binds collagen, starting thrombogenesis, and fibrin, stabilizing thrombi. GPVI‐dimers, not monomers, recognize immobilized fibrinogen and fibrin through their D‐domains. Collagen, D‐fragment and D‐dimer may share a common or proximate binding site(s) on GPVI‐dimer....
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| Pubblicato in: | J Thromb Haemost |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5838801/ https://ncbi.nlm.nih.gov/pubmed/29210180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13919 |
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