Rate-limiting roles of the tenase complex of factors VIII and IX in platelet procoagulant activity and formation of platelet-fibrin thrombi under flow

The importance of factor Xa generation in thrombus formation has not been studied extensively so far. Here, we used mice deficient in either factor VIII or factor IX to determine the role of platelet-stimulated tenase activity in the formation of platelet-fibrin thrombi on collagen. With tissue fact...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Swieringa, Frauke, Kuijpers, Marijke J. E., Lamers, Moniek M. E., van der Meijden, Paola E. J., Heemskerk, Johan W. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450620/
https://ncbi.nlm.nih.gov/pubmed/25769543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2014.116863
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