Suppressive Role of Tissue Factor Pathway Inhibitor-α in Platelet-Dependent Fibrin Formation under Flow Is Restricted to Low Procoagulant Strength

Tissue factor pathway inhibitor-alpha (TFPI-α) is a Kunitz-type serine protease inhibitor, which suppresses coagulation by inhibiting the tissue factor (TF)/factor VIIa complex as well as factor Xa. In static plasma-phospholipid systems, TFPI-α thus suppresses both factor Xa and thrombin generation....

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Publicado no:Thromb Haemost
Main Authors: Thomassen, Stella, Mastenbroek, Tom G., Swieringa, Frauke, Winckers, Kristien, Feijge, Marion A.H., Schrijver, Roy, Cosemans, Judith M.E.M., Maroney, Susan A., Mast, Alan E., Hackeng, Tilman M., Heemskerk, Johan W.M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880031/
https://ncbi.nlm.nih.gov/pubmed/29452445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0038-1627453
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