Combined Quantification of the Global Proteome, Phosphoproteome, and Proteolytic Cleavage to Characterize Altered Platelet Functions in the Human Scott Syndrome

The Scott syndrome is a very rare and likely underdiagnosed bleeding disorder associated with mutations in the gene encoding anoctamin-6. Platelets from Scott patients are impaired in various Ca(2+)-dependent responses, including phosphatidylserine exposure, integrin closure, intracellular protein c...

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Bibliografiske detaljer
Udgivet i:Mol Cell Proteomics
Main Authors: Solari, Fiorella A., Mattheij, Nadine J.A., Burkhart, Julia M., Swieringa, Frauke, Collins, Peter W., Cosemans, Judith M.E.M., Sickmann, Albert, Heemskerk, Johan W.M., Zahedi, René P.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5054341/
https://ncbi.nlm.nih.gov/pubmed/27535140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M116.060368
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