Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition

Adenosine diphosphate (ADP) enhances platelet activation by virtually any other stimulant to complete aggregation. It binds specifically to the G-protein–coupled membrane receptors P2Y1 and P2Y12, stimulating intracellular signaling cascades, leading to integrin αIIbβ3 activation, a process antagoni...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: Beck, Florian, Geiger, Jörg, Gambaryan, Stepan, Solari, Fiorella A., Dell’Aica, Margherita, Loroch, Stefan, Mattheij, Nadine J., Mindukshev, Igor, Pötz, Oliver, Jurk, Kerstin, Burkhart, Julia M., Fufezan, Christian, Heemskerk, Johan W. M., Walter, Ulrich, Zahedi, René P., Sickmann, Albert
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2017
Assuntos:
Plenary Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248936/
https://ncbi.nlm.nih.gov/pubmed/28060719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-05-714048
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