Structural and functional parameters of the flaviviral protease: a promising antiviral drug target

av Shiryaev, Sergey A, Strongin, Alex Y
Publicerad 2010

Heterocyclic Inhibitors of Viroporins in the Design of Antiviral Compounds

av Shiryaev, Vadim A., Klimochkin, Yuri N.
I publikationen Chem Heterocycl Compd (N Y) (2020)

Main Chemotypes of SARS-CoV-2 Reproduction Inhibitors

av Shiryaev, V. A., Klimochkin, Yu. N.
I publikationen Russ J Org Chem (2021)

Probing of Exosites Leads to Novel Inhibitor Scaffolds of HCV NS3/4A Proteinase

av Shiryaev, Sergey A., Cheltsov, Anton V., Strongin, Alex Y.
Publicerad 2012

Distinct Interactions with Cellular E-Cadherin of the Two Virulent Metalloproteinases Encoded by a Bacteroides fragilis Pathogenicity Island

av Remacle, Albert G., Shiryaev, Sergey A., Strongin, Alex Y.
I publikationen PLoS One (2014)

Peptide Sequence Region That is Essential for the Interactions of the Enterotoxigenic Bacteroides fragilis Metalloproteinase II with E-cadherin

av Shiryaev, Sergey A., Remacle, Albert G., Cieplak, Piotr, Strongin, Alex Y.
I publikationen J Proteolysis (2014)

Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold

av Aleshin, Alexander E., Shiryaev, Sergey A., Strongin, Alex Y., Liddington, Robert C.
Publicerad 2007

Virtual Ligand Screening of the National Cancer Institute (NCI) Compound Library Leads to the Allosteric Inhibitory Scaffolds of the West Nile Virus NS3 Proteinase

av Shiryaev, Sergey A., Cheltsov, Anton V., Gawlik, Katarzyna, Ratnikov, Boris I., Strongin, Alex Y.
Publicerad 2011

Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming

av Barile, Elisa, Baggio, Carlo, Gambini, Luca, Shiryaev, Sergey A., Strongin, Alex Y., Pellecchia, Maurizio
I publikationen Molecules (2020)

NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus

av Shiryaev, Sergey A., Chernov, Andrei V., Aleshin, Alexander E., Shiryaeva, Tatiana N., Strongin, Alex Y.
Publicerad 2009

The acidic sequence of the NS4A cofactor regulates ATP hydrolysis by the HCV NS3 helicase

av Shiryaev, Sergey A., Chernov, Andrei V., Shiryaeva, Tatiana N., Aleshin, Alexander E., Strongin, Alex Y.
Publicerad 2010

Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis

av Remacle, Albert G, Cieplak, Piotr, Hyun, Dong Nam, Shiryaev, Sergey A, Ge, Xin, Strongin, Alex Y
I publikationen Oncotarget (2016)

Cleavage preference distinguishes the two-component NS2B–NS3 serine proteinases of Dengue and West Nile viruses

av Shiryaev, Sergey A., Kozlov, Igor A., Ratnikov, Boris I., Smith, Jeffrey W., Lebl, Michal, Strongin, Alex Y.
Publicerad 2007

A Femtomol Range FRET Biosensor Reports Exceedingly Low Levels of Cell Surface Furin: Implications for the Processing of Anthrax Protective Antigen

av Gawlik, Katarzyna, Remacle, Albert G., Shiryaev, Sergey A., Golubkov, Vladislav S., Ouyang, Mingxing, Wang, Yingxiao, Strongin, Alex Y.
Publicerad 2010

Dynamic Interdomain Interactions Contribute to the Inhibition of Matrix Metalloproteinases by Tissue Inhibitors of Metalloproteinases

av Remacle, Albert G., Shiryaev, Sergey A., Radichev, Ilian A., Rozanov, Dmitri V., Stec, Boguslaw, Strongin, Alex Y.
Publicerad 2011

A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1–MMP

av Shiryaev, S A, Remacle, A G, Golubkov, V S, Ingvarsen, S, Porse, A, Behrendt, N, Cieplak, P, Strongin, A Y
Publicerad 2013

Expression and purification of a two-component flaviviral proteinase resistant to autocleavage at the NS2B-NS3 junction region

av Shiryaev, Sergey A., Aleshin, Alexander E., Ratnikov, Boris I., Smith, Jeffrey W., Liddington, Robert C., Strongin, Alex Y.
Publicerad 2006

Matrix Metalloproteinase Proteolysis of the Myelin Basic Protein Isoforms Is a Source of Immunogenic Peptides in Autoimmune Multiple Sclerosis

av Shiryaev, Sergey A., Savinov, Alexei Y., Cieplak, Piotr, Ratnikov, Boris I., Motamedchaboki, Khatereh, Smith, Jeffrey W., Strongin, Alex Y.
Publicerad 2009

Structure-activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase

av Sidique, Shyama, Shiryaev, Sergey A., Ratnikov, Boris I., Herath, Ananda, Su, Ying, Strongin, Alex Y., Cosford, Nicholas D. P.
Publicerad 2009

Matrix metalloproteinase proteolysis of the mycobacterial HSP65 protein as a potential source of immunogenic peptides in human tuberculosis

av Shiryaev, Sergey A., Cieplak, Piotr, Aleshin, Alexander E., Sun, Qing, Zhu, Wenhong, Motamedchaboki, Khatereh, Sloutsky, Alexander, Strongin, Alex Y.
Publicerad 2011