Cleavage preference distinguishes the two-component NS2B–NS3 serine proteinases of Dengue and West Nile viruses

Regulated proteolysis of the polyprotein precursor by the NS2B–NS3 protease is required for the propagation of infectious virions. Unless the structural and functional parameters of NS2B–NS3 are precisely determined, an understanding of its functional role and the design of flaviviral inhibitors wil...

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Detaylı Bibliyografya
Asıl Yazarlar: Shiryaev, Sergey A., Kozlov, Igor A., Ratnikov, Boris I., Smith, Jeffrey W., Lebl, Michal, Strongin, Alex Y.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Portland Press Ltd. 2007
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1770841/
https://ncbi.nlm.nih.gov/pubmed/17067286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061136
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