Isolation and characterization of selective and potent human Fab inhibitors directed to the active-site region of the two-component NS2B–NS3 proteinase of West Nile virus

There is a need to develop inhibitors of mosquito-borne flaviviruses, including WNV (West Nile virus). In the present paper, we describe a novel and efficient recombinant-antibody technology that led us to the isolation of inhibitory high-affinity human antibodies to the active-site region of a vira...

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Hlavní autoři: SHIRYAEV, Sergey A., RADICHEV, Ilian A., RATNIKOV, Boris I., ALESHIN, Alexander E., GAWLIK, Katarzyna, STEC, Boguslaw, FRISCH, Christian, KNAPPIK, Achim, STRONGIN, Alex Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958048/
https://ncbi.nlm.nih.gov/pubmed/20156198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20100074
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