Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase

Mosquito-borne WNV (West Nile virus) is an emerging global threat. The NS3 proteinase, which is essential for the proteolytic processing of the viral polyprotein precursor, is a promising drug target. We have isolated and biochemically characterized the recombinant, highly active NS3 proteinase. We...

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Bibliographic Details
Main Authors: Shiryaev, Sergey A., Ratnikov, Boris I., Chekanov, Alexei V., Sikora, Sergey, Rozanov, Dmitri V., Godzik, Adam, Wang, Jun, Smith, Jeffrey W., Huang, Ziwei, Lindberg, Iris, Samuel, Melanie A., Diamond, Michael S., Strongin, Alex Y.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2005
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360700/
https://ncbi.nlm.nih.gov/pubmed/16229682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051374
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