Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase

Mosquito-borne WNV (West Nile virus) is an emerging global threat. The NS3 proteinase, which is essential for the proteolytic processing of the viral polyprotein precursor, is a promising drug target. We have isolated and biochemically characterized the recombinant, highly active NS3 proteinase. We...

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Detalhes bibliográficos
Main Authors: Shiryaev, Sergey A., Ratnikov, Boris I., Chekanov, Alexei V., Sikora, Sergey, Rozanov, Dmitri V., Godzik, Adam, Wang, Jun, Smith, Jeffrey W., Huang, Ziwei, Lindberg, Iris, Samuel, Melanie A., Diamond, Michael S., Strongin, Alex Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360700/
https://ncbi.nlm.nih.gov/pubmed/16229682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051374
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