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The acidic sequence of the NS4A cofactor regulates ATP hydrolysis by the HCV NS3 helicase

In flaviviruses and hepatitis C virus (HCV), the NS3 gene encodes the N-terminal protease (NS3pro) and the C-terminal helicase (NS3hel). In HCV, the downstream NS4A is required for the NS3pro activity and exhibits a conserved EFDEMEE motif. To identify the role of this motif, we compared the ATPase...

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Main Authors: Shiryaev, Sergey A., Chernov, Andrei V., Shiryaeva, Tatiana N., Aleshin, Alexander E., Strongin, Alex Y.
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918179/
https://ncbi.nlm.nih.gov/pubmed/20978807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00705-010-0838-2
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