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The acidic sequence of the NS4A cofactor regulates ATP hydrolysis by the HCV NS3 helicase
In flaviviruses and hepatitis C virus (HCV), the NS3 gene encodes the N-terminal protease (NS3pro) and the C-terminal helicase (NS3hel). In HCV, the downstream NS4A is required for the NS3pro activity and exhibits a conserved EFDEMEE motif. To identify the role of this motif, we compared the ATPase...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3918179/ https://ncbi.nlm.nih.gov/pubmed/20978807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00705-010-0838-2 |
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