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Matrix Metalloproteinase Proteolysis of the Myelin Basic Protein Isoforms Is a Source of Immunogenic Peptides in Autoimmune Multiple Sclerosis

BACKGROUND: Matrix metalloproteinases (MMPs) play a significant role in the fragmentation of myelin basic protein (MBP) and demyelination leading to autoimmune multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). The classic MBP isoforms are predominantly expressed in the oli...

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Autori principali: Shiryaev, Sergey A., Savinov, Alexei Y., Cieplak, Piotr, Ratnikov, Boris I., Motamedchaboki, Khatereh, Smith, Jeffrey W., Strongin, Alex Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654159/
https://ncbi.nlm.nih.gov/pubmed/19300513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004952
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