Inflammatory Proprotein Convertase-Matrix Metalloproteinase Proteolytic Pathway in Antigen-presenting Cells as a Step to Autoimmune Multiple Sclerosis

Multiple sclerosis (MS) is a disease of the central nervous system with autoimmune etiology. Susceptibility to MS is linked to viral and bacterial infections. Matrix metalloproteinases (MMPs) play a significant role in the fragmentation of myelin basic protein (MBP) and demyelination. The splice var...

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Main Authors: Shiryaev, Sergey A., Remacle, Albert G., Savinov, Alexei Y., Chernov, Andrei V., Cieplak, Piotr, Radichev, Ilian A., Williams, Roy, Shiryaeva, Tatiana N., Gawlik, Katarzyna, Postnova, Tatiana I., Ratnikov, Boris I., Eroshkin, Alexei M., Motamedchaboki, Khatereh, Smith, Jeffrey W., Strongin, Alex Y.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Protein Synthesis, Post-Translational Modification, and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781616/
https://ncbi.nlm.nih.gov/pubmed/19726693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.041244
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