The Wnt/Planar Cell Polarity Protein-tyrosine Kinase-7 (PTK7) Is a Highly Efficient Proteolytic Target of Membrane Type-1 Matrix Metalloproteinase: IMPLICATIONS IN CANCER AND EMBRYOGENESIS

PTK7 is an essential component of the Wnt/planar cell polarity (PCP) pathway. We provide evidence that the Wnt/PCP pathway converges with pericellular proteolysis in both normal development and cancer. Here, we demonstrate that membrane type-1 matrix metalloproteinase (MT1-MMP), a key proinvasive pr...

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Autors principals: Golubkov, Vladislav S., Chekanov, Alexei V., Cieplak, Piotr, Aleshin, Alexander E., Chernov, Andrei V., Zhu, Wenhong, Radichev, Ilian A., Zhang, Danhua, Dong, P. Duc, Strongin, Alex Y.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975198/
https://ncbi.nlm.nih.gov/pubmed/20837484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.165159
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