Protein-tyrosine Pseudokinase 7 (PTK7) Directs Cancer Cell Motility and Metastasis

It is well established that widely expressed PTK7 is essential for vertebrate tissue morphogenesis. In cancer, the functionality of PTK7 is selectively regulated by membrane type-1 matrix metalloproteinase (MT1-MMP), ADAMs (a disintegrin domain and metalloproteinases), and γ-secretase proteolysis. H...

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Main Authors: Golubkov, Vladislav S., Prigozhina, Natalie L., Zhang, Yong, Stoletov, Konstantin, Lewis, John D., Schwartz, Phillip E., Hoffman, Robert M., Strongin, Alex Y.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148854/
https://ncbi.nlm.nih.gov/pubmed/25006253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.574459
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