Substrate Cleavage Profiling Suggests a Distinct Function of Bacteroides fragilis Metalloproteinases (Fragilysin and Metalloproteinase II) at the Microbiome-Inflammation-Cancer Interface

Enterotoxigenic anaerobic Bacteroides fragilis is a significant source of inflammatory diarrheal disease and a risk factor for colorectal cancer. Two distinct metalloproteinase types (the homologous 1, 2, and 3 isoforms of fragilysin (FRA1, FRA2, and FRA3, respectively) and metalloproteinase II (MPI...

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Main Authors: Shiryaev, Sergey A., Remacle, Albert G., Chernov, Andrei V., Golubkov, Vladislav S., Motamedchaboki, Khatereh, Muranaka, Norihito, Dambacher, Corey M., Capek, Petr, Kukreja, Muskan, Kozlov, Igor A., Perucho, Manuel, Cieplak, Piotr, Strongin, Alex Y.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2013
主題:
Molecular Bases of Disease
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843106/
https://ncbi.nlm.nih.gov/pubmed/24145028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.516153
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