Substrate Cleavage Profiling Suggests a Distinct Function of Bacteroides fragilis Metalloproteinases (Fragilysin and Metalloproteinase II) at the Microbiome-Inflammation-Cancer Interface

Enterotoxigenic anaerobic Bacteroides fragilis is a significant source of inflammatory diarrheal disease and a risk factor for colorectal cancer. Two distinct metalloproteinase types (the homologous 1, 2, and 3 isoforms of fragilysin (FRA1, FRA2, and FRA3, respectively) and metalloproteinase II (MPI...

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Bibliographic Details
Main Authors: Shiryaev, Sergey A., Remacle, Albert G., Chernov, Andrei V., Golubkov, Vladislav S., Motamedchaboki, Khatereh, Muranaka, Norihito, Dambacher, Corey M., Capek, Petr, Kukreja, Muskan, Kozlov, Igor A., Perucho, Manuel, Cieplak, Piotr, Strongin, Alex Y.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843106/
https://ncbi.nlm.nih.gov/pubmed/24145028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.516153
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