Matrix Metalloproteinase Proteolysis of the Myelin Basic Protein Isoforms Is a Source of Immunogenic Peptides in Autoimmune Multiple Sclerosis

BACKGROUND: Matrix metalloproteinases (MMPs) play a significant role in the fragmentation of myelin basic protein (MBP) and demyelination leading to autoimmune multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). The classic MBP isoforms are predominantly expressed in the oli...

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Bibliografiset tiedot
Päätekijät: Shiryaev, Sergey A., Savinov, Alexei Y., Cieplak, Piotr, Ratnikov, Boris I., Motamedchaboki, Khatereh, Smith, Jeffrey W., Strongin, Alex Y.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2009
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654159/
https://ncbi.nlm.nih.gov/pubmed/19300513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004952
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