A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1–MMP

Matrix metalloproteinases (MMPs) and, especially membrane type 1 (MT1)-MMP/MMP-14, are promising drug targets in malignancies. In contrast with multiple small-molecule and protein pan-inhibitors of MT1–MMP cleavage activity, the murine 9E8 monoclonal antibody targets the MMP-2-activating function of...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Shiryaev, S A, Remacle, A G, Golubkov, V S, Ingvarsen, S, Porse, A, Behrendt, N, Cieplak, P, Strongin, A Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940861/
https://ncbi.nlm.nih.gov/pubmed/24296749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2013.44
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados