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Timp-2 binding with cellular MT1-MMP stimulates invasion-promoting MEK/ERK signaling in cancer cells

Both invasion-promoting MT1-MMP and its physiological inhibitorTIMP-2 play a significant role in tumorigenesis and are identified in the most aggressive cancers. Despite its antiproteolytic effects in vitro, clinical data suggest that TIMP-2 expression is positively associated with tumor recurrence,...

詳細記述

保存先:
書誌詳細
主要な著者: Sounni, Nor Eddine, Rozanov, Dmitri V., Remacle, Albert G., Golubkov, Vladislav S., Noel, Agnes, Strongin, Alex Y.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864114/
https://ncbi.nlm.nih.gov/pubmed/19551841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.24690
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