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Dynamic Interdomain Interactions Contribute to the Inhibition of Matrix Metalloproteinases by Tissue Inhibitors of Metalloproteinases

Because of their important function, matrix metalloproteinases (MMPs) are promising drug targets in multiple diseases, including malignancies. The structure of MMPs includes a catalytic domain, a hinge, and a hemopexin domain (PEX), which are followed by a transmembrane and cytoplasmic tail domains...

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Detalhes bibliográficos
Main Authors: Remacle, Albert G., Shiryaev, Sergey A., Radichev, Ilian A., Rozanov, Dmitri V., Stec, Boguslaw, Strongin, Alex Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121501/
https://ncbi.nlm.nih.gov/pubmed/21518756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.200139
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