Dynamic Interdomain Interactions Contribute to the Inhibition of Matrix Metalloproteinases by Tissue Inhibitors of Metalloproteinases

Because of their important function, matrix metalloproteinases (MMPs) are promising drug targets in multiple diseases, including malignancies. The structure of MMPs includes a catalytic domain, a hinge, and a hemopexin domain (PEX), which are followed by a transmembrane and cytoplasmic tail domains...

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Detaylı Bibliyografya
Asıl Yazarlar: Remacle, Albert G., Shiryaev, Sergey A., Radichev, Ilian A., Rozanov, Dmitri V., Stec, Boguslaw, Strongin, Alex Y.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2011
Konular:
Enzymology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121501/
https://ncbi.nlm.nih.gov/pubmed/21518756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.200139
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