Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis

The invasion-promoting MT1-MMP is a cell surface-associated collagenase with a plethora of critical cellular functions. There is a consensus that MT1-MMP is a key protease in aberrant pericellular proteolysis in migrating cancer cells and, accordingly, a promising drug target. Because of high homolo...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Remacle, Albert G, Cieplak, Piotr, Hyun, Dong Nam, Shiryaev, Sergey A, Ge, Xin, Strongin, Alex Y
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356841/
https://ncbi.nlm.nih.gov/pubmed/27835863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13157
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