Non-destructive and Selective Imaging of the Functionally Active, Pro-invasive Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Enzyme in Cancer Cells

Proteolytic activity of cell surface-associated MT1-matrix metalloproteinase (MMP) (MMP-14) is directly related to cell migration, invasion, and metastasis. MT1-MMP is regulated as a proteinase by activation and conversion of the latent proenzyme into the active enzyme, and also via inhibition by ti...

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Autores principales: Remacle, Albert G., Shiryaev, Sergey A., Golubkov, Vladislav S., Freskos, John N., Brown, Michael A., Karwa, Amolkumar S., Naik, Arati D., Howard, Carol P., Sympson, Carolyn J., Strongin, Alex Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711321/
https://ncbi.nlm.nih.gov/pubmed/23733191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.471508
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