Proteasome inhibitors block Ikaros degradation by lenalidomide in multiple myeloma

Por Shi, Chang-Xin, Kortüm, Klaus Martin, Zhu, Yuan Xiao, Jedlowski, Patrick, Bruins, Laura, Braggio, Esteban, Stewart, A. Keith
Publicado no Haematologica (2015)

Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-κB with antimyeloma activity in vitro and in vivo

Por Tiedemann, Rodger E., Schmidt, Jessica, Keats, Jonathan J., Shi, Chang-Xin, Zhu, Yuan Xiao, Palmer, Stephen E., Mao, Xinliang, Schimmer, Aaron D., Stewart, A. Keith
Publicado em 2009

Chromosome Condensation 1-Like (Chc1L) Is a Novel Tumor Suppressor Involved in Development of Histiocyte-Rich Neoplasms

Por Spillane, David R., Wang, Ding Yan, Newbigging, Susan, Wang, Youdong, Shi, Chang-Xin, Cho, Hae-Ra, Shimizu, Hiroki, Gramolini, Anthony, Liu, Mingyao, Wen, Xiao-Yan
Publicado no PLoS One (2015)

Loss of FAM46C promotes cell survival in myeloma

Por Zhu, Yuan Xiao, Shi, Chang-Xin, Bruins, Laura A., Jedlowski, Patrick, Wang, Xuewei, Kortüm, K. Martin, Luo, Moulun, Ahmann, Jonathan M., Braggio, Esteban, Stewart, A. Keith
Publicado no Cancer Res (2017)

Characterization of the Novel Protein KIAA0564 (Von Willebrand Domain-Containing Protein 8)

Por Luo, Moulun, Mengos, April E., Ma, Wuqiong, Finlayson, Jean, Bustos, Rocio Zapata, Zhu, Yuan Xiao, Shi, Chang-Xin, Stubblefield, Tianna M., Willis, Wayne T., Mandarino, Lawrence J.
Publicado no Biochem Biophys Res Commun (2017)

RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5

Por Zhu, Yuan Xiao, Tiedemann, Rodger, Shi, Chang-Xin, Yin, Holly, Schmidt, Jessica E., Bruins, Laura A., Keats, Jonathan J., Braggio, Esteban, Sereduk, Chris, Mousses, Spyro, Stewart, A. Keith
Publicado em 2011

Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival

Por Xu, Qinqin, Hou, Yue-xian, Langlais, Paul, Erickson, Patrick, Zhu, James, Shi, Chang-Xin, Luo, Moulun, Zhu, Yuanxiao, Xu, Ye, Mandarino, Lawrence J., Stewart, Keith, Chang, Xiu-bao
Publicado no BMC Cancer (2016)

CRISPR genome-wide screening identifies dependence on the proteasome subunit PSMC6 for Bortezomib sensitivity in multiple myeloma

Por Shi, Chang-Xin, Kortüm, K. Martin, Zhu, Yuan Xiao, Bruins, Laura A., Jedlowski, Patrick, Votruba, Patrick G., Luo, Moulun, Stewart, Robert A., Ahmann, Jonathan, Braggio, Esteban, Stewart, A. Keith
Publicado no Mol Cancer Ther (2017)

RNA interference screening identifies lenalidomide sensitizers in multiple myeloma, including RSK2

Por Zhu, Yuan Xiao, Yin, Hongwei, Bruins, Laura A., Shi, Chang-Xin, Jedlowski, Patrick, Aziz, Meraj, Sereduk, Chris, Kortuem, Klaus Martin, Schmidt, Jessica E., Champion, Mia, Braggio, Esteban, Keith Stewart, A.
Publicado no Blood (2015)

Multiple myeloma cells’ capacity to decompose H(2)O(2) determines lenalidomide sensitivity

Por Sebastian, Sinto, Zhu, Yuan X., Braggio, Esteban, Shi, Chang-Xin, Panchabhai, Sonali C., Van Wier, Scott A., Ahmann, Greg J., Chesi, Marta, Bergsagel, P. Leif, Stewart, A. Keith, Fonseca, Rafael
Publicado no Blood (2017)

Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity

Por Tiedemann, Rodger E., Mao, Xinliang, Shi, Chang-Xin, Zhu, Yuan Xiao, Palmer, Stephen E., Sebag, Michael, Marler, Ron, Chesi, Marta, Fonseca, Rafael, Bergsagel, P. Leif, Schimmer, Aaron D., Stewart, A. Keith
Publicado em 2008

Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6

Por Tiedemann, Rodger E., Zhu, Yuan Xiao, Schmidt, Jessica, Yin, Hongwei, Shi, Chang-Xin, Que, Qiang, Basu, Gargi, Azorsa, David, Perkins, Louise M., Braggio, Esteban, Fonseca, Rafael, Bergsagel, P. Leif, Mousses, Spyro, Stewart, A. Keith
Publicado em 2010

Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide

Por Zhu, Yuan Xiao, Braggio, Esteban, Shi, Chang-Xin, Bruins, Laura A., Schmidt, Jessica E., Van Wier, Scott, Chang, Xiu-Bao, Bjorklund, Chad C., Fonseca, Rafael, Bergsagel, P. Leif, Orlowski, Robert Z., Stewart, A. Keith
Publicado em 2011

Extramedullary Myeloma whole genome sequencing reveals novel mutations in Cereblon, proteasome subunit G2 and the glucocorticoid receptor in multi drug resistant disease

Por Egan, Jan B., Kortuem, K. Martin, Kurdoglu, Ahmet, Izatt, Tyler, Aldrich, Jessica, Reiman, Rebecca, Phillips, Lori, Baker, Angela, Shi, Chang-Xin, Schmidt, Jessica, Liang, Winnie S., Craig, David W., Carpten, John D., Stewart, A. Keith
Publicado em 2013

Combined venetoclax and alvocidib in acute myeloid leukemia

Por Bogenberger, James, Whatcott, Clifford, Hansen, Nanna, Delman, Devora, Shi, Chang-Xin, Kim, Wontak, Haws, Hillary, Soh, Katherine, Lee, Ye Sol, Peterson, Peter, Siddiqui-Jain, Adam, Weitman, Steven, Stewart, Keith, Bearss, David, Mesa, Ruben, Warner, Steven, Tibes, Raoul
Publicado no Oncotarget (2017)

Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides

Por Egan, Jan B., Shi, Chang-Xin, Tembe, Waibhav, Christoforides, Alexis, Kurdoglu, Ahmet, Sinari, Shripad, Middha, Sumit, Asmann, Yan, Schmidt, Jessica, Braggio, Esteban, Keats, Jonathan J., Fonseca, Rafael, Bergsagel, P. Leif, Craig, David W., Carpten, John D., Stewart, A. Keith
Publicado em 2012

Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma

Por Zhu, Yuan Xiao, Braggio, Esteban, Shi, Chang-Xin, Kortuem, K. Martin, Bruins, Laura A., Schmidt, Jessica E., Chang, Xiu-Bao, Langlais, Paul, Luo, Moulun, Jedlowski, Patrick, LaPlant, Betsy, Laumann, Kristina, Fonseca, Rafael, Bergsagel, P. Leif, Mikhael, Joseph, Lacy, Martha, Champion, Mia D., Stewart, A. Keith
Publicado em 2014

Whole Genome Analyses of a Well-Differentiated Liposarcoma Reveals Novel SYT1 and DDR2 Rearrangements

Por Egan, Jan B., Barrett, Michael T., Champion, Mia D., Middha, Sumit, Lenkiewicz, Elizabeth, Evers, Lisa, Francis, Princy, Schmidt, Jessica, Shi, Chang-Xin, Van Wier, Scott, Badar, Sandra, Ahmann, Gregory, Kortuem, K. Martin, Boczek, Nicole J., Fonseca, Rafael, Craig, David W., Carpten, John D., Borad, Mitesh J., Stewart, A. Keith
Publicado em 2014

The clinical significance of cereblon expression in multiple myeloma

Por Schuster, Steven R., Kortuem, K. Martin, Zhu, Yuan Xiao, Braggio, Esteban, Shi, Chang-Xin, Bruins, Laura A., Schmidt, Jessica E., Ahmann, Greg, Kumar, Shaji, Rajkumar, S. Vincent, Mikhael, Joseph, LaPlant, Betsy, Champion, Mia D., Laumann, Kristina, Barlogie, Bart, Fonseca, Rafael, Bergsagel, P. Leif, Lacy, Martha, Stewart, A. Keith
Publicado em 2013

Targeted sequencing using a 47 gene multiple myeloma mutation panel (M(3)P) in -17p high risk disease

Por Kortüm, Klaus M., Langer, Christian, Monge, Jorge, Bruins, Laura, Egan, Jan B., Zhu, Yuan X., Shi, Chang Xin, Jedlowski, Patrick, Schmidt, Jessica, Ojha, Juhi, Bullinger, Lars, Liebisch, Peter, Kull, Miriam, Champion, Mia D., Van Wier, Scott, Ahmann, Gregory, Rasche, Leo, Knop, Stefan, Fonseca, Rafael, Einsele, Hermann, Stewart, A Keith, Braggio, Esteban
Publicado no Br J Haematol (2014)