The clinical significance of cereblon expression in multiple myeloma

Cereblon (CRBN) mediates immunomodulatory drug (IMiD) action in multiple myeloma (MM). We demonstrate here that no patient with very low CRBN expression responded to IMiD plus dexamethasone therapy. In 53 refractory MM patients treated with pomalidomide and dexamethasone, CRBN levels predict for dec...

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Hauptverfasser: Schuster, Steven R., Kortuem, K. Martin, Zhu, Yuan Xiao, Braggio, Esteban, Shi, Chang-Xin, Bruins, Laura A., Schmidt, Jessica E., Ahmann, Greg, Kumar, Shaji, Rajkumar, S. Vincent, Mikhael, Joseph, LaPlant, Betsy, Champion, Mia D., Laumann, Kristina, Barlogie, Bart, Fonseca, Rafael, Bergsagel, P. Leif, Lacy, Martha, Stewart, A. Keith
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905958/
https://ncbi.nlm.nih.gov/pubmed/24129344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2013.08.015
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