Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide

The precise molecular mechanism of action and targets through which thalidomide and related immunomodulatory drugs (IMiDs) exert their antitumor effects remains unclear. We investigated the role of cereblon (CRBN), a primary teratogenic target of thalidomide, in the antimyeloma activity of IMiDs. CR...

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Main Authors: Zhu, Yuan Xiao, Braggio, Esteban, Shi, Chang-Xin, Bruins, Laura A., Schmidt, Jessica E., Van Wier, Scott, Chang, Xiu-Bao, Bjorklund, Chad C., Fonseca, Rafael, Bergsagel, P. Leif, Orlowski, Robert Z., Stewart, A. Keith
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2011
Teme:
Plenary Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208291/
https://ncbi.nlm.nih.gov/pubmed/21860026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-05-356063
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